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TB-500

Thymosin Beta-4 Active Fragment
Also: Thymosin Beta-4 Fragment

Molecular weight
4963 Da (full TB4)
Sequence
Ac-SDKP (N-terminal active region)

Reviewed

Overview

TB-500 is a synthetic version of Thymosin Beta-4 (TB4), a naturally occurring 43-amino acid peptide found in high concentrations in blood platelets, wound fluid, and various tissues. Thymosin Beta-4 is one of the most abundant proteins in the cytoplasm, comprising up to 0.5-2% of total cellular protein in many cell types.

The primary function of TB4 involves regulation of actin, a fundamental protein in cell structure and motility. TB4 sequesters G-actin (monomeric actin) and prevents its polymerization into F-actin (filamentous actin), playing crucial roles in cell migration, wound healing, and tissue regeneration.

Mechanism of action

TB-500/Thymosin Beta-4 functions through several key mechanisms:

Actin Regulation TB4 binds to G-actin with high affinity, preventing spontaneous polymerization. This pool of sequestered actin can be rapidly mobilized during cellular processes requiring cytoskeletal reorganization, such as cell migration and wound healing.

Cell Migration Promotion By regulating actin dynamics, TB4 enhances cell motility, which is essential for wound repair. It promotes migration of keratinocytes, endothelial cells, and other cell types involved in healing.

Angiogenesis Stimulation TB4 promotes new blood vessel formation by enhancing endothelial cell migration and differentiation. The peptide upregulates various angiogenic factors and promotes capillary tube formation.

Anti-inflammatory Effects Research indicates TB4 can modulate inflammatory responses by affecting cytokine production and immune cell activity, potentially reducing excessive inflammation during injury.

Research applications

Key points

  1. 1

    Synthetic fragment of Thymosin Beta-4

  2. 2

    Primary actin-sequestering protein

  3. 3

    Promotes cell migration and motility

  4. 4

    Upregulated in wound fluid and healing tissue

  5. 5

    Involved in cardiac repair research

Sources

  1. Goldstein AL, et al. (2005). Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. (opens PubMed in a new tab) Trends Mol Med.
  2. Smart N, et al. (2007). Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. (opens PubMed in a new tab) Nature.

Researching TB-500?

Read the certificate before you order. Every peptide we sell is blind-tested by PepScan Australia, and below 98% purity is rejected.

Shop TB-500All guides

For research use only. This information is for education and research. This compound is intended for laboratory research and is not approved for human consumption. Consult the scientific literature and follow local regulations.