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KLOW Peptide Blend

GHK-Cu + BPC-157 + TB-500 + KPV Blend

Reviewed

Overview

KLOW is a four-peptide blend in one vial: GHK-Cu, BPC-157, TB-500 and KPV. Its PepScan certificate reports the measured content of each compound separately (about 71mg GHK-Cu, 12mg BPC-157, 11mg TB-500 and 12mg KPV in the 80mg vial), so the composition is printed rather than proprietary.

It is GLOW with KPV added. KPV is the C-terminal tripeptide of alpha-MSH, studied in inflammatory signalling research, so KLOW is used where tissue-remodelling and inflammatory pathways are studied together.

Mechanism of action

KLOW combines four mechanisms, one per component:

GHK-Cu A copper-binding tripeptide studied for its effects on collagen synthesis and on gene expression related to tissue remodelling.

BPC-157 A pentadecapeptide studied in tissue-repair and angiogenesis models.

TB-500 A synthetic thymosin beta-4 fragment that binds G-actin, studied in cell-migration research.

KPV The Lys-Pro-Val tripeptide from the C-terminus of alpha-MSH, studied for its effect on NF-kB inflammatory signalling in epithelial and immune cells.

Combined Research Researchers use the blend to study remodelling and inflammatory pathways together. Each component's content is reported separately on the PepScan certificate.

Research applications

Key points

  1. 1

    Four peptides: GHK-Cu, BPC-157, TB-500 and KPV

  2. 2

    Each component measured on the certificate

  3. 3

    GLOW with KPV added

  4. 4

    Used where remodelling and inflammation are studied together

  5. 5

    One vial instead of four

Sources

  1. Pickart L, et al. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. (opens PubMed in a new tab) Int J Mol Sci.
  2. Pickart L, et al. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. (opens PubMed in a new tab) Biomed Res Int.
  3. Seiwerth S, et al. (2018). BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing. (opens PubMed in a new tab) Curr Pharm Des.
  4. Chang CH, et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. (opens PubMed in a new tab) J Appl Physiol (1985).
  5. Goldstein AL, et al. (2005). Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. (opens PubMed in a new tab) Trends Mol Med.
  6. Smart N, et al. (2007). Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. (opens PubMed in a new tab) Nature.
  7. Dalmasso G, et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. (opens PubMed in a new tab) Gastroenterology.
  8. Kannengiesser K, et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. (opens PubMed in a new tab) Inflamm Bowel Dis.

Researching KLOW Peptide Blend?

Read the certificate before you order. Every peptide we sell is blind-tested by PepScan Australia, and below 98% purity is rejected.

Shop KLOW Peptide BlendAll guides

For research use only. This information is for education and research. This compound is intended for laboratory research and is not approved for human consumption. Consult the scientific literature and follow local regulations.